[深圳]香港中文大学（深圳）科比尔卡创新药物开发研究院

职位：实验室工程师|高级实验室工程师
发布时间：2020-08-14
工作地点：深圳
信息来源：高校人才网
职位类型：全职
职位描述
简介

科比尔卡创新药物开发研究院（KIIDD）是香港中文大学（深圳）组建的首批诺贝尔奖科学家实验室之一。研究院的重点研究领域集中在新药开发上，研究方向主要包括药物受体结构生物学研究、药物计算化学研究、功能药物分子的有机合成和药物化学的研究、受体功能药物分子的功能药理学等。通过X射线单晶衍射、核磁共振和冷冻电子显微学等方法进行药物受体结构生物学研究，借助计算机辅助和分子模拟进行药物设计，对功能药物分子合成和药物化学、药理学原理进行研究，进行对新型药物进行合成制备，为今后的临床研究提供药理学理论支撑。

本次招聘的岗位隶属于香港中文大学（深圳）科比尔卡冷冻电子显微中心，它是KIIDD在深圳市龙岗区政府的大力支持下，历时一年打造的高性能冷冻电子显微平台，也是龙岗区第一个结构生物学平台。中心致力于建设成具有国际一流核心技术和分析能力的高端科研平台，与世界顶尖高校开展深度合作与交流，推动研究院产学研创新和突破，开展龙岗区和深圳在相关领域的产业化和项目转化。

科比尔卡冷冻电子显微中心是由提供有偿服务的设施，工作人员在将冷冻电镜成像应用于他们的研究中的过程中，为研究院的研究发展提供专业支持。（建议修改：科比尔卡冷冻电子显微中心是以提供有偿服务的设施为基础，由工作人员在将冷冻电镜成像应用于科研人员的研究过程，为研究院的研究发展提供专业支持的平台。）中心与科研人员紧密合作，确定最佳的实验设计方案，包括样品制备策略，维护和操作低温电子显微镜以及辅助设备以提供高分辨率图像，以及在数据管理和分析方面提供指导和服务。

职位描述

工作职责：

帮助维护和操作冷冻电子显微镜如TitanKrios及相关设备

帮助定期进行电镜流程测试并优化电镜性能以进行数据收集

参与冷冻电镜的方法开发/优化

与具有不同经验水平的用户互动/对其进行培训

维护设施日常运行记录

岗位要求：

结构生物学，生物化学，生物物理学，材料科学或相关领域的博士，有经验的硕士也将考虑

2-3年的cryo-EM经验，包括处理样品，使用显微镜和图像评估

了解透射电子显微镜和3D结构确定的原理

对cryo-EM工作流程的有一般了解

乐于学习新技术并应对新挑战

愿意参加开发/测试新方法/技术

团队协作能力，沟通能力强

申请程序

请准备好完整的中、英文简历发送至邮箱：liuzheng@，邮件标题注明：应聘岗位 毕业学校 本人姓名 。

Brief Introduction

Kobilka Institute of Innovative Drug Discovery is one of the first batch of Nobel laureate labs at the University. Led by Prof. Brian K. Kobilka, the Nobel laureate in Chemistry in 2012, the Kobilka Institute of Innovative Drug Discovery (KIIDD) is a significant milestone in the University's attempt to evolve into a world research university.

KIIDD will focus on new drug development which includes drugs receptor structural biology research, computational chemistry research, the function of the drug molecules in organic synthesis and medicinal chemistry research, receptor function the function of the drug molecule pharmacology, etc. Researchers in KIIDD are going to carry out studies about the structural biology of drug receptors through lots of modern biological techniques, such as single crystal x-ray diffraction, Nuclear magnetic resonance (NMR) and electron microscopy. CAD and molecular simulations were used in the drug designs. KIIDD lay eyes on functional drug synthesis, medicinal chemistry and pharmacology, to further explore the pathways to make new drugs, as well as offering intellectual support on pharmacology for future clinical research.

The Kobilka Cryo-EM center is a fee-for-service facility operated by the KIIDD at Chinese University of Hongkong(Shenzhen) as a state-of-the-art shared resource for biomedical researchers. The Cryo-EM staff members develop and provide their knowledge and expertise to the research community at KIIDD in applying cryo-EM imaging to their research. They work closely with investigators to define optimal experimental design including strategies for preparation of samples, maintain and operate cryo-electron microscopes and ancillary equipment in order to provide high resolution images, and provide guidance and service in data management and analysis.

The successful candidate will assist facility staff with maintenance and operation of the advanced instrumentation housed in the Cryo-EM core and will work with and train users in specimen preparation. The candidate will also be responsible for record keeping associated with users, instrument logs, and routine operation of the facility. The candidate will be expected to learn new procedures as they are developed and implemented by the facility.

Post Specification

Preferred Qualifications:

M.S in structural biology, biophysics, biochemistry, material science or related field, Ph.D would be a plus

2-3 years of experience in cryo-EM including handling samples, using microscopes and evaluation of images

Knowledge of the principles of transmission electron microscopy and 3D structure determination

General understanding of cryo-EM workflow

Excellent communication and interpersonal skills

Motivated to learn new technologies and to take on new challenges

Willing to develop/test new methods/techniques

Excellent organizational skills and record keeping

Special consideration will be given to candidates with a record of achievement in collaborative, team-driven environments

Responsibilities:

Help maintain and operate cryo electron microscopes and related equipment

Regularly benchmark and optimize microscope performance for data collection

Participate in method developments/optimization for cryo-EM

Interact closely with/train users with different levels of experience

Maintain record of daily operations in the facility

Application Procedure

Please send a full curriculum vitae by email to liuzheng@

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