[北京]首都医学科学创新中心闫啸实验室

职位：博士后|科研助理
发布时间：2026-10-01
工作地点：北京
信息来源：高校人才网
职位类型：全职
职位描述
首都医学科学创新中心闫啸实验室2026年招聘博士后、科研助理

共计2个岗位，招 若干人

五险一金 带薪年假 定期/免费体检 补充医疗保险 专业培训

基本信息

发布时间：2026-09-30

截止日期：2027-03-28

学历要求：硕士研究生及以上

需求学科（供参考）：
生物学

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公告详情

一、中心简介

首都医学科学创新中心[Chinese Institutes for Medical Research (CIMR), Beijing]（简称创新中心）是北京市2023年11月成立的具有独立法人资格的新型研发机构。作为首都医科大学新校区建设三大板块之一，创新中心以推动医学科学发展、改善人类健康为目标，开展生物医学研究，致力于提升医学科学创新与成果转化能力，提高疾病诊断和治疗水平。我们将汇聚世界高水平科学家，与首都医学教育和科学研究优质资源紧密合作，打造多学科交叉融合的科研平台，综合自由探索、医学目标导向、有组织科研等途径，实践新型科研模式和体制机制，培养适应医学科学创新发展的优秀人才，推进医教研产的深度融合，助力首都医科大学成为世界一流的医科大学。

二、实验室介绍

闫啸实验室（Condensates & Disease Lab, CD Lab）于2026年成立于首都医学科学创新中心（CIMR）和首都医科大学（CCMU），聚焦生物分子凝聚体（biomolecular condensates）、蛋白质异常聚集与神经退行性疾病的研究。

闫啸教授毕业于德国马克斯·普朗克生物化学研究所（Max Planck Institute of Biochemistry），师从蛋白质折叠领域先驱Franz-Ulrich Hartl教授；博士后期间在德国马克斯普朗克分子细胞生物学与遗传学研究所（MPI-CBG）工作，师从生物分子凝聚体领域奠基人Anthony Hyman教授。相关研究成果发表于Cell、Nature等学术期刊。

三、主要研究方向

闫啸实验室研究相分离（phase separation）驱动形成的生物大分子凝聚体（biomolecular condensates）—细胞内动态液态组装体—的物理化学特性，及其失控如何驱动渐冻症（ALS）和额颞叶痴呆（FTD）等神经退行性疾病的发生发展。实验室围绕致病蛋白聚集机制、结构演变路径、凝聚体病理及AI辅助分子诊疗策略四个方向，构建以凝聚体为核心的疾病研究框架。

四、主要研究成果

1. 发现凝聚体内二次相分离（intra-condensate demixing）这一新机制，揭示TDP-43蛋白如何在凝聚体中由动态功能状态转变为病理性聚集（Yan et al., Cell 2025）。

2. 发现相分离驱动β-羧酶体自发组装（Wang et al., Nature 2019）。

3. 发现GroEL/GroES分子伴侣系统中的环分离（ring separation）机制（Yan et al., Cell 2018）。

五、代表性文章

1. Yan X, Kuster D, Mohanty P, et al. Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates. Cell, 2025, 188: 1-18.

2. Wang H, Yan X, Aigner H, et al. Rubisco condensate formation by CcmM in β-carboxysome biogenesis. Nature, 2019, 566: 131-135. (* Co-first author)

3. Yan X, Shi Q, Bracher A, et al. GroEL ring separation and exchange in the chaperonin reaction. Cell, 2018, 172: 605-617.

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六、博士后（2名）

（一）
主要职责

1. 在PI指导下独立开展研究工作；

2. 协助指导研究生以及撰写论文和基金申请。

（二）
任职要求

1. 近期获得或即将获得博士学位，具有以下科研背景者优先：生物化学与结构生物学、AI for Biology、神经生物学、类器官与干细胞研究、细胞生物学、单细胞组学或空间组学；

2. 以第一作者身份在领域内主流期刊上发表过或即将发表研究论文；

3. 具备独立开展科研工作能力，具有高涨的科研热情、严谨的科研态度、良好的沟通能力和团队合作精神；

4. 具备良好的英语读写和日常交流能力，能够使用英文撰写论文。

七、科研助理（1-2名）

（一）
主要职责

1. 独立或协助团队开展课题研究；

2. 协助实验室运行管理。

（二）
任职要求

1. 硕士学历及以上，具有以下科研背景者优先：生物化学与结构生物学、AI for Biology、神经生物学、类器官与干细胞研究、细胞生物学、单细胞组学或空间组学；

2. 诚实严谨，具备良好的沟通能力和团队协作能力；

3. 具备良好的英语读写和日常交流能力。

八、福利待遇

1. 根据应聘者的工作经验和能力，提供具有市场竞争力的薪酬（详情面谈）；

2. 享受五险一金、带薪年假、体检和补充医疗保险等；

3. 支持个人职业发展，提供必要的工作相关专业培训。

九、申请方法

请将个人简历、研究经历简介、代表性论文及2名推荐人联系方式（限博士后岗位），以及其他证明研究能力的材料合并为1个PDF文件，发送至 yanxiao@，请【点击下方“立即投递/投递简历”，即刻进行职位报名】，并在邮件主题中注明申请人的姓名和具体职位。

联系人：闫老师

联系地址：北京市丰台区右安门外西头条10号-首都医学科学创新中心

本招聘长期有效，至招聘到合适人选为止。

ABOUT CIMR

Chinese Institutes for Medical Research (CIMR), Beijing is a research institution committed to advancing basic and translational medical research. Founded in November 2023 as one of the three core pillars of the newly established Capital Medical University, CIMR focuses on addressing fundamental issues in human health by leveraging cutting-edge technologies and conducting interdisciplinary collaborations with world-class scientists and clinicians based in Beijing. CIMR also offers outstanding education and training programs for the next generation of medical scientists. Adhering to a science-oriented governance and operational framework to drive innovation in research and education, we are dedicated to helping Capital Medical University to become a world-class leading medical university.

Laboratory Introduction

The Yan Xiao Laboratory (Condensates & Disease Lab, CD Lab) was established in 2026 at the Capital Institute of Medical Science and Innovation (CIMR) and Capital Medical University (CCMU), focusing on research into biomolecular condensates, abnormal protein aggregation and neurodegenerative diseases.

The laboratory is led by Dr. Yan Xiao, who earned his PhD at the Max Planck Institute of Biochemistry in Germany under Professor Franz-Ulrich Hartl, a pioneer in protein folding. He then completed postdoctoral research at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) in Germany, under Professor Anthony Hyman, a founding figure in the field of biomolecular condensates. His work has been published in journals including Cell and Nature.

Major Research Projects

The Yan laboratory studies biomolecular condensates — dynamic, liquid-like assemblies that cells use to organize RNA and proteins — and how their breakdown drives amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two devastating neurodegenerative diseases. We are building a condensate-centric framework for these diseases around four connected questions:

1. Aggregation mechanism. We view protein aggregation not as an isolated event, but as a network-driven process triggered when condensates fail under stress, transitioning from functional assemblies into pathological aggregates.

2. Structural landscapes. We map the structural routes proteins take as they aggregate inside condensates, tracking how disordered and structured regions change conformation en route to pathological states.

3. Condensate pathology. We dissect how this condensate dysfunction mechanistically drives disease onset.

4. Diagnostics and therapeutics. Building on these mechanistic and structural insights, we apply AI-guided protein design toward early diagnosis and therapeutic intervention.

Major Contributions

1. Linked condensate biophysics to ALS/FTD. We discovered intra-condensate demixing as a novel mechanism driving TDP-43 aggregation, revealing a fundamental link between condensate physics and neurodegenerative disease (Cell, 2025).

2. Revealed phase separation as an organelle-building principle. We showed liquid-liquid phase separation drives de novo assembly of β-carboxysomes (Nature, 2019).

3. Defined chaperone mechanisms in protein folding. We uncovered the ring separation mechanism of the GroEL/GroES chaperonin system, a key step in protein folding (Cell, 2018).

Representative Publications

1. Yan X, Kuster D, Mohanty P, et al. Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates. Cell, 2025, 188: 1-18.

2. Wang H, Yan X, Aigner H, et al. Rubisco condensate formation by CcmM in β-carboxysome biogenesis. Nature, 2019, 566: 131-135.(* Co-first author)

3. Yan X, Shi Q, Bracher A, et al. GroEL ring separation and exchange in the chaperonin reaction. Cell, 2018, 172: 605-617.

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Open Positions

Postdoctoral Fellows (2 Positions)

Main Responsibilities

a. Conduct independent research projects under the supervision and guidance of the Principal Investigator (PI).

b. Assist in mentoring graduate students and contribute to preparing research manuscripts and grant proposals.

Qualifications

a. Applicants should have recently obtained, or be expected to obtain, a Ph.D. degree. Candidates with research experience in the following areas are preferred: biochemistry and structural biology, AI for Biology, neuroscience, organoid and stem cell research, cell biology, single-cell omics, or spatial omics.

b. Applicants should have published, or have a manuscript accepted or in preparation, as first author in a leading peer-reviewed journal in the relevant field.

c. Candidates should demonstrate the ability to conduct research independently, together with strong enthusiasm for scientific research, a rigorous and responsible attitude, effective communication skills, and a collaborative mindset.

d. Good command of written and spoken English is required, including the ability to prepare scientific manuscripts in English.

Research Assistants (1–2 Positions)

Main Responsibilities

a. Independently conduct or assist with research projects within the laboratory.

b. Assist with the day-to-day operation and management of the laboratory.

Qualifications

a. Applicants should hold a Master’s degree or above. Candidates with research experience in the following areas are preferred: biochemistry and structural biology, AI for Biology, neuroscience, organoid and stem cell research, cell biology, single-cell omics, or spatial omics.

b. Candidates should demonstrate integrity, a rigorous scientific attitude, strong communication skills, and the ability to work effectively as part of a team.

c. Good proficiency in written and spoken English is required.

Welfare Treatment

a. Competitive salary based on the applicant’s work experience and ability (salary negotiable).

b. Social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.

c. Opportunities for career development and available professional guidance.

How to apply

Please combine your curriculum vitae, a brief summary of your research experience, representative publications, contact information for two referees (required for postdoctoral applicants only), and any other materials demonstrating your research capabilities into a single PDF file and send it to yanxiao@cimrbj.ac.cn. Please indicate your name and the specific position you are applying for in the subject line of the email.

Contact person: Dr. Yan

Applications are accepted on a rolling basis, and the positions remain open until suitable candidates are recruited.

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