首页 > 其它 全职 > 职位详细
说明:

此信息由高校人才网审核并发布(查看原发布网址),应届生求职网转载该信息只是出于传递更多就业招聘信息,促进大学生就业的目的。如您对此转载信息有疑义,请与原信息发布者高校人才网核实,并请同时联系本站处理该转载信息。

[浙江]浙江中医药大学生命科学学院Ivan Psakhye教授团队

职位:博士后
发布时间:2025-07-16
工作地点:其它
信息来源:高校人才网
职位类型:全职
专业标签:生物科学
职位描述
浙江中医药大学生命科学学院Ivan Psakhye教授团队2025年招聘全职博士后

共计1个岗位,招 若干人

餐饮补贴

基本信息

发布时间:2025-07-15

截止日期:详见正文

学历要求:博士研究生

需求学科(供参考):
生物学

展开

公告详情

浙江中医药大学生命科学学院 Ivan Psakhye教授团队长期招聘全职博士后,具体内容详见下方招聘信息 Opportunities for Postdocs in the laboratory of Ivan Psakhye SUMO and Ubiquitin Pathways in Genome Stability

Opportunities for Postdocs in the laboratory of Ivan Psakhye SUMO and Ubiquitin Pathways in Genome Stability

Employer:Zhejiang Chinese Medical University

Location:Hangzhou, Zhejiang, China

Salary:300,000 CNY annually plus competitive bonus determined by the level of experience, skill set and progress of the fellow.

Benefits:Medical insurance, campus food allowance and subsidized campus accommodation.

Starting date:October 1st, 2025. The starting date is flexible from October 1st2025, and applications will be reviewed on a rolling basis until the positions are filled.

Job Type: Postdoctoral

Employment: Full time

Duration: 3 years. The appointment is fully supported for 3 years, after which the position may be further extended if required.

Qualification:PhD

Research:

Our newly established laboratory at Zhejiang Chinese Medical University is currently seeking enthusiastic young scientists to join us as postdoctoral fellows. Our aim is to conduct fundamental mechanistic research with a focus on functional aspects related to the SUMO and ubiquitin pathways. Moreover, we have a general interest in DNA replication, DNA repair, sister chromatid cohesion, genome stability and chromatin biology, in particular if ubiquitin family proteins are involved. Because of the available tools for rapid and elegant genetic manipulation, budding yeast Saccharomyces cerevisiae is ideally suited for the mechanistic cell biology studies we conduct in the lab. To extend the significance of the findings made in yeast to a more universal level, key mechanistic insights will be validated also in mammalian cells.

Posttranslational modification (PTM) of proteins by attachment of ubiquitin (ubiquitylation) is best known for its function to label proteins for degradation by the proteasome. However, ubiquitylation plays non-proteolytic roles as well, e.g. for DNA repair, gene expression and signal transduction. Another member of the ubiquitin family, Small Ubiquitin-like Modifier (SUMO), functions primarily in the non-proteolytic (non-proteasomal) manner. It affects protein-protein interactions, interplays with the ubiquitin pathway, controls DNA repair, replication, sister chromatid cohesion and supports genome stability.

Ubiquitin typically targets individual proteins and high selectivity is provided by a plethora of ubiquitin-conjugating enzymes and ligases. Much less is known regarding how modification by the ubiquitin-related protein SUMO influences the function of its targets and how substrate specificity is achieved. Surprisingly, although thousands of proteins are modified by SUMO, only a handful of enzymes participate in the pathway. Moreover, although SUMO modification is essential for viability, mutants defective in SUMOylation of individual substrates typically lack deleterious phenotypes. We previously discovered that SUMOylation operates strategically different from ubiquitylation as it often targets entire groups of proteins that are spatially and functionally connected rather than individual substrates (Psakhye and Jentsch, Cell, 2012). In protein-group modification SUMO functions as intermolecular glue thereby stabilizing dynamic macromolecular protein complexes and concentrating activities. Thus, the traditional view that a single PTM on a given substrate mediates a specific function does not seem to apply for many SUMO modifications.

In our laboratory, we will focus on the principles of protein-group modification and its special requirements for specificity, formation, timing, and disassembly. We will expand the concept of protein-group SUMOylation with a focus on pathways relevant for cellular physiology, genome integrity in particular, and which are of medical importance. The broad scientific goal of the laboratory will be to advance the understanding of the general mechanisms and functions of the SUMO pathway, and its interplay with other PTM systems.

Below find the examples of the kind of research that we conduct for further reading:

Psakhye and Jentsch, Cell, 2012. DOI: do***org[点击查看]

Lu, Psakhye and Jentsch, Cell, 2014. DOI: do***org[点击查看]

Psakhye, Castellucci and Branzei, Mol Cell, 2019. DOI: do***org[点击查看]

Psakhye and Branzei, Cell Rep, 2021. DOI: do***org[点击查看]

Psakhye et al., Nat Struct Mol Biol, 2023. DOI: 10.1038/s41594-023-01064-x

A few things to consider:

In our laboratory you can work on significant biological questions of general importance.

Because our scientific interest is broad, you get in contact with a wide range of biological topics and have the choice of different projects.

Our techniques and methods range from yeast genetics, protein biochemistry, cell biology, proteomics, microscopy to whole genome sequencing and advanced genetic and interaction screens.

We have many opportunities for international collaborations and English is our working language.

Qualifications:

Applicants should have a strong interest in cell biology or molecular biology and high motivation to uncover the molecular mechanisms. We are conducting basic research and are mainly interested in discovering new cellular functions or principles rather than studying details.Postdoc candidates are expected with a record of successful research in the areas of molecular biology, cell biology, biochemistry, or genetics.

How to apply?

To apply, please forward a curriculum vitae, bibliography, and the names and addresses of referees to Prof. Ivan Psakhye: ivan.psakhye@

信息来源于网络,如有变更请以原发布者为准。

来源链接:

rc***.cn[点击查看]

附件/来源打开异常提示
附件下载异常:因平台URL协议兼容性原因,公告正文附件材料可能存在无法下载情况,届时您可复制附件链接并新建页面打开查看。

来源链接打开异常:若文中 来源链接XXX 无法正常打开,属内容来源网站异常情况,本平台无法监控处理,如有需求,可持续关注相应链接修复情况。

[我要纠错]

公告热度

解锁详细分析

该公告在同类公告中的热度为 ***,目前已有 *** 对其非常感兴趣

欢迎扫描下方二维码关注官方微信(硕博QQ交流群:748436790 ,进微信群请点击添加官方客服号


重要风险提示:如招聘单位在招聘过程中向求职者提出收取押金、保证金、体检费、材料费、成本费,或指定医院体检等,求职者有权要求招聘单位出具物价部门批准的收费许可证明材料,若无法提供相关证明,请求职者提高警惕,有可能属于诈骗或违规行为。

登录打开APP 查看全部

上一条:[广东]云浮市云城区机关事业单位

下一条:[重庆]重庆外语外事学院国际传媒学院

相关招聘信息:

[湖南]湖南得一睿行生物科技有限公司 生产技术员|产品技术研发人员|行政文员|实习生产技术员(2025-07-16,其它) [其它]南京大学“脑机智能成像与生物通讯实验室” 博士后研究人员(2025-07-16,其它 南京) [浙江其它]温州医科大学附属第二医院 博士后(2025-07-16,其它) [山东其它]山东第一医科大学(山东省医学科学院) ['讲席教授', '特聘教授', '杰出学者', '拔尖学者', '骨干学者', '青年学者'](2025-07-16,其它) [深圳]深圳职业技术大学 教师|研究人员|教辅人员|行政人员(2025-07-16,深圳 其它) 中国林业科学研究院 出站博士后(2025-07-16,上海 北京 广州 南京 深圳 武汉 天津 成都 其它)