[北京]首都医学科学创新中心姜汉杰实验室

职位：博士后|科研助理
发布时间：2025-03-11
工作地点：北京
信息来源：高校人才网
职位类型：全职
专业标签：外国文学 生物科学 化学 药学 设计学 基础医学
职位描述
首都医学科学创新中心姜汉杰实验室2025年招聘博士后、科研助理

共计2个岗位，招 若干人

五险一金 带薪年假 定期/免费体检 补充医疗保险 专业培训

基本信息

发布时间：2025-03-11

截止日期：2025-09-10

学历要求：本科及以上

公告详情

一、中心简介

首都医学科学创新中心（简称创新中心）是北京市新成立的具有独立法人资格的新型研发机构。创新中心以推动医学科学发展、改善人类健康为目标，开展生物医学研究，致力于提升医学科学创新与成果转化能力，提高疾病诊断和治疗水平。我们将汇聚世界高水平科学家，与首都医学教育和科学研究优质资源紧密合作，打造多学科交叉融合的科研平台，综合自由探索、医学目标导向、有组织科研等途径，实践新型科研模式和体制机制，逐步推进医教研产的深度融合，培养适应医学科学创新发展的优秀人才。

二、实验室介绍

首都医学科学创新中心姜汉杰课题组现面向国内外招聘博士后与科研助理，课题组专注于利用化学生物学方法解码蛋白质翻译后修饰在癌症和其他疾病中的功能，并探索潜在的疾病治疗策略。课题组坚持科学点亮生活，鼓励开放交流，支持成员学习成长，希望认真研究同时认真生活，立志为癌症等疾病贡献新的解题思路。如果你想一边和志同道合的人们研究前沿科学，一边享受实验室的快乐氛围，赶紧看过来！

姜汉杰研究员毕业于北京大学，本硕阶段的导师为蒲小平教授，于2022年在约翰霍普金斯大学获得药理学与分子科学的博士学位，师从PhilipCole教授，期间主要研究泛素连接酶的功能调节和底物识别机制，之后继续在哈佛医学院/布莱根妇女医院完成了博士后训练，应用化学生物学手段探究泛素连接酶的催化机制。姜汉杰研究员于2025年2月加入首都医学科学创新中心。

三、主要研究方向

1.开发和应用蛋白质半合成、分子探针等化学方法，研究酶及细胞信号通路中的蛋白质磷酸化、泛素化等翻译后修饰。

2.探索蛋白质泛素及类泛素修饰的调控机制以及其在疾病发生中的病理机制，鉴别新的治疗靶点。

3.开发靶向泛素化的合成生物学工具，为基础研究和疾病治疗提供新方法。

四、主要成果

1.发现HECT家族E3连接酶末端羧基参与泛素转移的催化机制。

2.揭示HECT家族E3连接酶中的自抑制和激活机制。

3.开发特异性的蛋白质N端标记方法。

代表性文章

Jiang?et al., 2024, Nature Chemistry, PMID:39030419

Jiang et al., 2022, JBC, PMID:35331737

Jiang et al., 2019, JBC, PMID:31578285

Dempsey, Jiang et al., 2018, JACS, PMID:30016585

Chen, Jiang et al., 2017, Molecular Cell, PMID:28475870

五、岗位信息

01博士后

1）任职要求

1.近三年已获得或即将获得生命科学、化学、药学或相关专业的博士学位，具有生物化学与分子生物学、药理学、蛋白设计、药物开发等研究背景者优先考虑；

2.有责任心和团队精神，诚实诚信，心态阳光，热爱创新与挑战;

3.能独立地开展科研工作；

4.具备较好的英文沟通、写作能力。

02科研助理

1）任职要求

1.本科及以上学历，生命科学、化学、药学、医学等相关专业；

2.可独立或协助开展实验室研究工作，管理和维护实验室的日常事务；

3.有责任心和团队精神，诚实诚信，心态阳光，热爱创新与挑战；

4.具备基本的英文沟通、写作能力。

六、福利待遇

1.根据应聘者的工作经验和能力，提供具有市场竞争力的薪酬（详情面谈）；

2.享受五险一金、带薪年假、体检和补充医疗保险等；

3.支持个人职业发展，提供必要的工作相关专业培训；协助申报各类科研基金和人才项目。

七、申请方法

请将简历、个人陈述（1页）、2名推荐人的基本信息和联系方式、工作总结与研究兴趣（1-2页，仅限博士后）以及其他申请人认为必要的材料，合并为PDF文件发送至hjiang@，请【点击下方“立即投递/投递简历”，即刻进行职位报名】，并在邮件主题中注明：“应聘博士后/科研助理 本人姓名 所在学校/单位”，初审通过的申请者将会尽快安排面试。

联系人：姜老师

联系地址：北京市丰台区右安门外西头条10号-首都医学科学创新中心

本招聘长期有效，至招聘到合适人选为止。

ABOUT CIMR

The Chinese Institutes for Medical Research (CIMR) is a newly founded institution dedicated to fundamental and translational medical research. The CIMR is located at the main campus of the Capital Medical University, Beijing, China and committed to building a scientist-centered governance framework and fostering a diverse and inclusive work environment. For more information, please visit our website: ww***.cn[点击查看]

Laboratory Introduction

The Jiang lab at CIMR now has open positions for postdoctoral fellows and research assistants. The lab is dedicated to using chemical biology approaches to decode the functions of protein post-translational modifications (PTMs) in cancer and other diseases, with a focus on advancing innovative therapeutic strategies. We firmly believe science makes life better, encourage open communication, and fully support our members in learning and personal development. Our goal is to balance dedicated research with a fulfilling life. We are committed to contributing to new solutions for cancer and other diseases. If you’re after cutting-edge science mixed with a fun and supportive lab environment, read on!

Dr. Jiang graduated from Peking University with Bachelor’s and Master’s degrees under the supervision of Dr. Xiaoping Pu. He received his Ph.D. degree in Pharmacology and Molecular Sciences from the Johns Hopkins University with Dr. Philip Cole in 2022, where he studied the regulation mechanisms and substrate selectivity of HECT family E3 ligases. He then completed his postdoc training in the Cole lab at Harvard Medical School and Brigham and Women’s Hospital, where he focused on illustrating the catalytic mechanisms of HECT E3 ligases using chemical biology approaches. Dr. Jiang joined CIMR faculty in February, 2025.

Major Research Projects

a. Developing and applying chemical methods, such as protein semisynthesis and molecular probes, to investigate protein ubiquitination, phosphorylation, and other PTMs in key enzyme and cellular signaling pathways.

b. Exploring the regulatory mechanisms of ubiquitin and ubiquitin-like modifications and their pathological roles in disease progression to identify novel therapeutic targets.

c. Designing and optimizing synthetic biology tools for targeted ubiquitination to provide innovative methods for basic research and translational medicine.

Major Contributions

a. Discovered the catalytic role of terminal carboxylate involvement in ubiquitin transfer by HECT E3 ligases.

b. Uncovered the autoinhibition and activation mechanisms in HECT E3 ligases.

c. Developed a specific protein N-terminal labeling method.

Representative Publications

Jiang et al., 2024, Nature Chemistry, PMID:39030419

Jiang et al., 2022, JBC, PMID:35331737

Jiang et al., 2019, JBC, PMID:31578285

Dempsey, Jiang et al., 2018, JACS, PMID:30016585

Chen, Jiang et al., 2017, Molecular Cell, PMID:28475870

Open Positions

Postdoctoral Researcher

Qualifications

a. Have obtained or be about to obtain (within the past three years) a Ph.D. in life science, chemistry, pharmacology or a related field. Candidates with a strong background in fields, such as biochemistry and molecular biology, pharmacology, protein design or targeted-based drug development are preferred.

b. Highly responsible, honest with a positive mindset, and unafraid of trying new approaches.

c. Capable of conducting research independently.

d. Competent in English communication and writing skills.

Research Assistant

Qualifications

a. Bachelor’s degree or above in life sciences, chemistry, medicine, or a related field.

b. Capable of conducting research collaboratively or independently; Able to assist with daily lab operations.

c. Highly responsible, honest with a positive mindset, and unafraid of trying new approaches.

d. Basic English communication and writing skills are required.

Welfare Treatment

a. Provide competitive salary based on the applicant’s work experience and ability (salary negotiable).

b. Provide social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.

c. Support career development, provide relevant professional guidance, and support grant or talent program applications.

How to apply

Please compile your CV, one-page personal statement, basic information and contact details of two referees and a 1-2 page research summary and interests (for postdoc position only), ?as well as other materials demonstrating research capabilities into a single PDF file. Send it to hjiang@, and indicate “Postdoc/Research Assistant Your Name University/Employer” in the email subject. Review of applications will begin on a rolling basis, and qualified applicants will be invited for an interview.

Contact person: Dr. Jiang

This recruitment is valid for the long term until a suitable candidate is recruited.

信息来源于网络，如有变更请以原发布者为准。

来源链接：

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